The overall birth-defect rate was similar in the two treatment groups, but there were four major congenital anomalies in the letrozole group and one in the clomiphene group; this difference was not significant but given the group size, we cannot rule out a potential difference. clomid before and after Human chorionic gonadotropin hCG , such as Novarel, Ovidrel, Pregnyl, and Profasi.